Sellomics | CAPTURING THE COMPLEXITY OF THE HUMAN GUT
Altis Biosystems
Reproducible and scalable human intestine platform for ADME-Tox, DMPK & IBD studies
Sellomics
Comparison with Caco-2
Testing PGP-mediated Efflux in RepliGut® Planar vs Caco-2
GI Toxicity
Screen compounds for drug-induced GI toxicity earlier in development.
Inflammatory Response
Evaluate pro- and anti- inflammatory effects of new modalities.
Intestinal Drug Disposition
Broaden bioavailability insights compared to Caco-2 cells.
Intestinal Barrier Function
Characterize barrier integrity in response to challenges.
What are the Advantages of Working with Sellomics?
How we can help you getting your research from good to great
We are a small but experienced team, and take every project individually from the first to the last step
We believe that “possible” is defined by the amount of energy invested. For your priority projects, you need a reliable partner going the extra mile.
Project failure is not an option. If anything happens during the project, we restart at no extra cost and without delay.
RepliGut® Systems
Altis Biosystems has pioneered the creation of Repligut® Systems, a collection of in vitro models derived from stem cells and designed specifically for pre-clinical drug discovery. RepliGut® models are designed to replicate the complex structure of the human small intestine and colonic epithelium using a standard user friendly format.
RepliGut models deliver valuable data insights, rapid screening capabilities, and an unparalleled biobank of ethically sourced donor intestinal cells, paving the way for more effective compound screening, disease modeling, and microbiome research.
Multiple Regions and Formats Available
RepliGut® Planar kits can include stem cells from any one of 5 distinct intestinal regions. They are all available in 12-well or 96-well transwell plates.
Small Intestine
- Duodenum
- Jejunum
Colon
- Ascending Colon
- Transverse Colon
- Descending Colon
RepliGut® Planar Model
How does it work?
The Stem Cells isolated from the crypts are seeded on the cell culture inserts and expanded for 5 days until confluence. Afterwards the medium is changed to a differentiation medium and cells start polarizing and differentiating for the following 5 days. During the maturation phase, cells form a tight barrier, produce mucus, differentiate in enterocytes/goblet cells/enteroendocrine cells and express characteristic markers.
For Biology & Pharmaceuticals
Sellomics as a Solution Partner
No drug is born equal, and every project is different. Our team have supported dozens of projects and takes pride in supporting each researcher in their work as they would expect from a colleague.
Step 1
We sign an NDA and make sure we have clarity on goals, budget and timelines. You want to get results soon, we are here to make this happen.
Step 2
With a pilot study you can collect the first results and flexibly evaluate the next steps. Our team will support you in drafting the study and finding the most flexible and cost effective solution.
Step 3
Once the first results are in, you’ll need a reliable partner. Sellomics will help you scale your research and offer a partnership approach to long-term studies that ensures you meet milestones in time and on budget.
InflammaScreen Services
